Good news, everyone! The September challenge is gonna be Futurama themed!

Another point of difference between The Simpsons and Futurama, at least to me, is a feeling that the latter had more overt Antagonists. Sure, edges would get sanded on and off over the series run, but you still had a range of characters with modus operandi ranging from wanton murder to world domination or planetary destruction.
So for today, What are your favorite and least favorite Futurama Villains?

Bonus prompt: What are the best and worst showcases of them?

Cancellation Bonus prompt: Any of them who have run their course as antagonists and/or fare better as more comedic supporting characters?

Revival Bonus Prompt: Any you feel are underused?